{"id":69922,"date":"2026-05-14T14:49:20","date_gmt":"2026-05-14T13:49:20","guid":{"rendered":"https:\/\/www.easly.nl\/difference-ozempic-wegovy-mounjaro-saxenda\/"},"modified":"2026-05-14T14:49:30","modified_gmt":"2026-05-14T13:49:30","slug":"difference-ozempic-wegovy-mounjaro-saxenda","status":"publish","type":"post","link":"https:\/\/www.easly.nl\/en\/difference-ozempic-wegovy-mounjaro-saxenda\/","title":{"rendered":"Ozempic, Wegovy, Mounjaro or Saxenda: what is actually the difference?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"69922\" class=\"elementor elementor-69922 elementor-69886\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b60c910 e-flex e-con-boxed e-con e-parent\" data-id=\"b60c910\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-211c02d elementor-widget elementor-widget-text-editor\" data-id=\"211c02d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>You have undoubtedly heard the names mentioned. In the newspaper, at the coffee machine, perhaps from your GP. Ozempic, Wegovy, Mounjaro, Saxenda\u2014they are all mentioned in the same breath as the \u2018weight loss jab\u2019. But are they the same drugs? And if they differ, in what way?<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d44dbc elementor-widget elementor-widget-text-editor\" data-id=\"4d44dbc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This is a question I receive almost daily as a pharmacist. And honestly, it is confusing. Even people who have already started a course of treatment sometimes do not know exactly what is in their prescription or why that particular medication was chosen.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72b6fbd elementor-widget elementor-widget-text-editor\" data-id=\"72b6fbd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In this article, I objectively compare the four most important GLP-1 medicines: the active ingredient, their registered uses, injection frequency, and what science says about their effectiveness. No sales pitch, no \u2018best remedy\u2019\u2014that doesn\u2019t exist. Just clarity, so you can have a better conversation with your doctor.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7a1a2b elementor-widget elementor-widget-text-editor\" data-id=\"d7a1a2b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><strong>\u26a0\ufe0f Important legal framework:<\/strong> This article is intended solely as factual education. It is not an advertisement for a specific medicine and not a recommendation for one medicine over another. The mentioned medicines are prescription medicines; the choice and prescription are reserved exclusively for a qualified doctor, based on your individual situation. Always consult a doctor or pharmacist for personal advice.<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-deabd70 e-flex e-con-boxed e-con e-parent\" data-id=\"deabd70\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0bf95ca elementor-widget elementor-widget-heading\" data-id=\"0bf95ca\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What do they have in common? All four work under the GLP-1 system.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b2ca333 e-flex e-con-boxed e-con e-parent\" data-id=\"b2ca333\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-454c5be elementor-widget elementor-widget-text-editor\" data-id=\"454c5be\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Let&#8217;s start with the similarities. All four agents mentioned belong to the class of <em>GLP-1 receptor agonists<\/em> or an extension thereof. As you read in blog 2, this class works on three fronts: delayed gastric emptying, inhibition of the hunger center in the brain, and more stable blood sugar.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1db65c elementor-widget elementor-widget-text-editor\" data-id=\"c1db65c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The differences lie in four things: the active ingredient, the indication for which they are registered, how often you inject, and the strength of the effect in clinical studies. It is like with cars: they all drive, but the engine, the fuel type, and what they are made for differ.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-334ffc9 e-flex e-con-boxed e-con e-parent\" data-id=\"334ffc9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-792c2e3 elementor-widget elementor-widget-heading\" data-id=\"792c2e3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The comparison at a glance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-604950f e-flex e-con-boxed e-con e-parent\" data-id=\"604950f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-683af98 elementor-widget elementor-widget-text-editor\" data-id=\"683af98\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The table below shows the key differences. The figures mentioned are from published phase 3 studies.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e2c357 e-flex e-con-boxed e-con e-parent\" data-id=\"4e2c357\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1b50d77 elementor-widget elementor-widget-shortcode\" data-id=\"1b50d77\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-243\" class=\"tablepress tablepress-id-243 blog-ldl-cortizol\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Brand Name<\/th><th class=\"column-2\">Brand NameActive IngredientRegistered ForWeight Loss in StudiesFrequency<\/th><th class=\"column-3\">Registered For<\/th><th class=\"column-4\">Weight Loss in Studies<\/th><th class=\"column-5\">Frequency<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"row-2\">\n\t<td class=\"column-1\">Ozempic\u00ae<\/td><td class=\"column-2\">Semaglutide<\/td><td class=\"column-3\">Type 2 Diabetes<\/td><td class=\"column-4\">Not registered for weight loss<\/td><td class=\"column-5\">1\u00d7 per week<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">Wegovy\u00ae<\/td><td class=\"column-2\">Semaglutide<\/td><td class=\"column-3\">Obesity \/ Overweight with comorbidities<\/td><td class=\"column-4\">~14.9% after 68 weeks<\/td><td class=\"column-5\">1\u00d7 per week<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">Mounjaro\u00ae<\/td><td class=\"column-2\">Tirzepatide<\/td><td class=\"column-3\">Type 2 Diabetes; Obesity (in EU)<\/td><td class=\"column-4\">~15\u201322.5% after 72 weeks<\/td><td class=\"column-5\">1\u00d7 per week<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">Saxenda\u00ae<\/td><td class=\"column-2\">Liraglutide<\/td><td class=\"column-3\">Obesity \/ Overweight with comorbidities<\/td><td class=\"column-4\">~8% after 56 weeks<\/td><td class=\"column-5\">Daily<\/td>\n<\/tr>\n<\/tbody>\n<tfoot>\n<tr class=\"row-6\">\n\t<th colspan=\"5\" class=\"column-1\">The study results were obtained in combination with a lifestyle intervention (nutrition, exercise, guidance). The figures do not constitute an individual guarantee; effectiveness varies per person.<\/th>\n<\/tr>\n<\/tfoot>\n<\/table>\n<!-- #tablepress-243 from cache --><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-39c6eef e-flex e-con-boxed e-con e-parent\" data-id=\"39c6eef\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2cef376 elementor-widget elementor-widget-heading\" data-id=\"2cef376\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The four remedies, one by one<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a30a981 e-flex e-con-boxed e-con e-parent\" data-id=\"a30a981\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e293a10 elementor-widget elementor-widget-text-editor\" data-id=\"e293a10\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>Ozempic\u00ae the well-known name from the news<\/b><\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a79cc2b elementor-widget elementor-widget-text-editor\" data-id=\"a79cc2b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ozempic contains semaglutide and is registered in Europe for the treatment of type 2 diabetes. It is therefore formally not a weight-loss drug. Ozempic became so well-known because people with diabetes who used Ozempic also lost significant weight. This additional observation led to follow-up research with a higher dosage of the same substance, which became Wegovy.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6e2cbb elementor-widget elementor-widget-text-editor\" data-id=\"f6e2cbb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The fact that Ozempic is sometimes prescribed by doctors \u2018off-label\u2019 for weight loss is a subject of discussion within the medical profession. Off-label use means that a doctor prescribes a medication for something other than that for which it was approved; this is only permitted in specific circumstances and after careful consideration.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0593d36 e-flex e-con-boxed e-con e-parent\" data-id=\"0593d36\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d20bf2f elementor-widget elementor-widget-text-editor\" data-id=\"d20bf2f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"padding-left: 40px;\"><b>Please note: why do you receive Ozempic instead of Wegovy at some companies?<\/b><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dfa3ef6 elementor-widget elementor-widget-text-editor\" data-id=\"dfa3ef6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"padding-left: 40px;\">In practice, it happens that weight loss and lifestyle clinics in the Netherlands prescribe Ozempic to people who want to lose weight, even though Wegovy is the drug formally approved for that purpose. The reason is almost always financial: Ozempic is significantly cheaper per month than Wegovy (roughly \u20ac150\u2013\u20ac250 versus \u20ac250\u2013\u20ac480 per month, as of 2026). That price difference can be tempting for both the clinic and the patient. However, it does not change what the law states.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46733e5 elementor-widget elementor-widget-text-editor\" data-id=\"46733e5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"padding-left: 40px;\"><strong>What does the law say?<\/strong><\/p>\n<p style=\"padding-left: 40px;\">According to Article 68, paragraph 1 of the Medicines Act, a doctor may only prescribe a medication off-label if protocols or standards exist within the medical profession that substantiate this use, or (when these are under development) after consultation with a pharmacist. This is not the case for prescribing Ozempic as a weight-loss medication: both the Dutch College of General Practitioners (NHG) and the Medicines Evaluation Board (CBG) urge doctors not to prescribe Ozempic off-label for weight loss.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5f882f elementor-widget elementor-widget-text-editor\" data-id=\"f5f882f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"padding-left: 40px;\">Legal-scientific analyses in the Nederlands Juristenblad (2024) and the Nederlands Tijdschrift voor Geneeskunde (2024) explicitly conclude that the off-label prescribing of Ozempic for weight loss does not fall within the legal framework. This does not mean that it is punishable by definition, but it does mean that the physician is in a legally vulnerable position and can be held accountable under disciplinary law.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a064fd8 elementor-widget elementor-widget-text-editor\" data-id=\"a064fd8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"padding-left: 40px;\"><strong>Our position at Easly:<\/strong><\/p>\n<p style=\"padding-left: 40px;\">If semaglutide is chosen for weight loss, we prescribe Wegovy. This is not only the legally correct route, but it is also a matter of due care and collegial responsibility.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6988bbe e-flex e-con-boxed e-con e-parent\" data-id=\"6988bbe\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a455eaf elementor-widget elementor-widget-text-editor\" data-id=\"a455eaf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>Wegovy\u00ae same substance, specifically for weight loss<\/b><\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10ae8bc elementor-widget elementor-widget-text-editor\" data-id=\"10ae8bc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Wegovy also contains semaglutide with exactly the same active ingredient as Ozempic. The difference lies in two things: the registration and the dosage. Wegovy has been specifically approved by the European Medicines Agency (EMA) for the treatment of obesity or overweight with weight-related health problems, and is available in a higher maximum dosage (up to 2.4 mg per week).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd2b129 elementor-widget elementor-widget-text-editor\" data-id=\"bd2b129\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In the STEP 1 registration study, published in <em>The New England Journal of Medicine<\/em> (2021), participants lost an average of 14.9% of their body weight after 68 weeks in combination with a lifestyle intervention.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e7a28f4 elementor-widget elementor-widget-text-editor\" data-id=\"e7a28f4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Please note: In the Netherlands (as of 2025), Wegovy is not reimbursed under basic health insurance for the indication obesity.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34cfd17 e-flex e-con-boxed e-con e-parent\" data-id=\"34cfd17\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b747f28 elementor-widget elementor-widget-text-editor\" data-id=\"b747f28\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>Mounjaro\u00ae the newer dual action<\/b><\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d62a401 elementor-widget elementor-widget-text-editor\" data-id=\"d62a401\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mounjaro contains tirzepatide and is different from the other three in that sense: it is not only a GLP-1 receptor agonist, but also a GIP receptor agonist.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64551c6 elementor-widget elementor-widget-text-editor\" data-id=\"64551c6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>What does that mean in practice? In addition to the GLP-1 hormone you are already familiar with, tirzepatide also mimics GIP hormone, a second gut hormone that is also involved in appetite and blood sugar. Studies show that the combination of both effects appears to lead to more potent results. In the SURMOUNT-1 study (NEJM, 2022), participants lost an average of 15% (5 mg dose) to 22.5% (15 mg dose) of their body weight after 72 weeks of treatment.[4] A follow-up study over 3 years (176 weeks) showed that most participants largely retained this weight with continued treatment.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a6a46e4 elementor-widget elementor-widget-text-editor\" data-id=\"a6a46e4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mounjaro was originally registered for type 2 diabetes and has since also received European approval for the treatment of obesity. Mounjaro is also a prescription medicine, and the prescribing physician determines whether it is a suitable option for your situation.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-54dca9c e-flex e-con-boxed e-con e-parent\" data-id=\"54dca9c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b58eabf elementor-widget elementor-widget-text-editor\" data-id=\"b58eabf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>Saxenda\u00ae the daily option<\/b><\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3542872 elementor-widget elementor-widget-text-editor\" data-id=\"3542872\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Saxenda contains liraglutide and was for a long time the only GLP-1 agonist specifically registered for weight reduction in Europe. Its action is similar to the other agents, but liraglutide has a shorter duration of action, which means you must inject daily instead of weekly.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-837defc elementor-widget elementor-widget-text-editor\" data-id=\"837defc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In clinical research, Saxenda leads to an average weight loss of approximately 8% after 56 weeks. This is less than semaglutide or tirzepatide, but Saxenda now has more long-term experience and is one of the options mentioned in the NHG Standard for Obesity (2025).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c0bf431 e-flex e-con-boxed e-con e-parent\" data-id=\"c0bf431\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-481fba8 elementor-widget elementor-widget-heading\" data-id=\"481fba8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What determines which product is suitable for you?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7b4b931 e-flex e-con-boxed e-con e-parent\" data-id=\"7b4b931\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bdab388 elementor-widget elementor-widget-text-editor\" data-id=\"bdab388\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A frequently asked question is: \u2018Which medication is best?\u2019 The honest answer is: that depends on your personal situation. Below, I list the factors that your doctor or pharmacist takes into account.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0efc889 elementor-widget elementor-widget-text-editor\" data-id=\"0efc889\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li><strong>Medical indication:<\/strong> Do you have type 2 diabetes, obesity, or both? This determines which medication falls within the registration.<\/li>\n<li><strong>BMI and comorbidity:<\/strong> The NHG Standard (2025) uses specific threshold values \u200b\u200bfor considering drug treatment.[8]<\/li>\n<li><strong>Contraindications:<\/strong> For example, a personal or family history of medullary thyroid carcinoma or MEN-2 syndrome excludes GLP-1 medication.<\/li>\n<li><strong>Practical preference:<\/strong> Weekly injections versus daily injections; both have advantages and disadvantages.<\/li>\n<li><strong>Costs and availability:<\/strong> Not all medications are reimbursed, and prices vary considerably.<\/li>\n<li><strong>Previous experience and side effects:<\/strong> If a previous medication was not well tolerated, a switch may sometimes be possible.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b617dd4 elementor-widget elementor-widget-text-editor\" data-id=\"b617dd4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>These are exactly the topics you discuss during a medical intake. Not \u2018which pen would you like today\u2019, but: is this medication, or GLP-1 medication in general, right for you?<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c5a4c8b e-flex e-con-boxed e-con e-parent\" data-id=\"c5a4c8b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-95bd61b elementor-widget elementor-widget-heading\" data-id=\"95bd61b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Three misunderstandings I often hear<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34bce5c e-flex e-con-boxed e-con e-parent\" data-id=\"34bce5c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-703bd2d elementor-widget elementor-widget-text-editor\" data-id=\"703bd2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>Misunderstanding 1: \u201cOzempic is a weight loss drug\u201d<\/b><\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8381fae elementor-widget elementor-widget-text-editor\" data-id=\"8381fae\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ozempic is not registered in the Netherlands and Europe for weight loss, but for type 2 diabetes. The hype surrounding Ozempic has obscured this picture and has even led to shortages for diabetes patients who genuinely need the medication. Anyone seeking a prescription for weight loss is formally on Wegovy (if semaglutide is chosen).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-66125cc e-flex e-con-boxed e-con e-parent\" data-id=\"66125cc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0df4136 elementor-widget elementor-widget-text-editor\" data-id=\"0df4136\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>Misunderstanding 2: \u201cThe stronger the effect, the better the remedy\u201d<\/b><\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e1cc3e elementor-widget elementor-widget-text-editor\" data-id=\"8e1cc3e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>It is tempting to view Mounjaro as the \u2018best\u2019 due to the higher weight loss percentage in studies. However, stronger does not automatically mean suitable for everyone. Greater effect can also mean more side effects, and some people tolerate a less potent product better. The goal is responsible weight loss, not maximum weight loss.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fd05a84 e-flex e-con-boxed e-con e-parent\" data-id=\"fd05a84\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d12d4f0 elementor-widget elementor-widget-text-editor\" data-id=\"d12d4f0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>Misunderstanding 3: \u201cIf I stop, the weight loss will be maintained\u201d<\/b><\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-012dca6 elementor-widget elementor-widget-text-editor\" data-id=\"012dca6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This is perhaps the most important misconception. In both the STEP 1 extension and real-world data, it is clear that after discontinuation of GLP-1 medication, a large portion of the lost weight often returns unless there is long-term lifestyle change. This is not a failure: it shows that obesity is a chronic condition, just like high blood pressure.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e34fbe9 e-flex e-con-boxed e-con e-parent\" data-id=\"e34fbe9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6958d4f elementor-widget elementor-widget-heading\" data-id=\"6958d4f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The conclusion: there is no \u2018best\u2019, there is a \u2018suitable\u2019<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-39c9cae e-flex e-con-boxed e-con e-parent\" data-id=\"39c9cae\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-02deca1 elementor-widget elementor-widget-text-editor\" data-id=\"02deca1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ozempic, Wegovy, Mounjaro, and Saxenda each have their own profile. What works perfectly for one person is not the right choice for another. Science provides the evidence; your doctor translates that to your individual situation; your pharmacist guides you in its use.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e390335 elementor-widget elementor-widget-text-editor\" data-id=\"e390335\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>As a pharmacist, it costs me no effort to be clear about this: if someone has a conversation with me about GLP-1 medication, that person is entitled to honest information, including all sides of the story.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1927af9 e-flex e-con-boxed e-con e-parent\" data-id=\"1927af9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7a7d0d elementor-widget elementor-widget-heading\" data-id=\"c7a7d0d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Next blog: is GLP-1 right for me?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a753712 e-flex e-con-boxed e-con e-parent\" data-id=\"a753712\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-192afb7 elementor-widget elementor-widget-text-editor\" data-id=\"192afb7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Now that you know the differences, the next question might be: is GLP-1 medication suitable for my situation? In blog 4, we will go through the criteria: BMI limits, comorbidities, contraindications, and when a doctor will or will not consider it.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-54610cf e-flex e-con-boxed e-con e-parent\" data-id=\"54610cf\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bb0ef2d elementor-widget elementor-widget-heading\" data-id=\"bb0ef2d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Stay up to date with our latest GLP-1 blogs<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3753695 elementor-widget elementor-widget-text-editor\" data-id=\"3753695\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Do you want to be the first to receive new blogs, insights, and updates regarding GLP-1? Leave your email address and stay informed about the latest developments, practical tips, and relevant information on GLP-1 and health.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ac24f9 elementor-button-align-stretch elementor-widget elementor-widget-form\" data-id=\"2ac24f9\" data-element_type=\"widget\" data-settings=\"{&quot;button_width&quot;:&quot;33&quot;,&quot;step_next_label&quot;:&quot;Next&quot;,&quot;step_previous_label&quot;:&quot;Previous&quot;,&quot;step_type&quot;:&quot;number_text&quot;,&quot;step_icon_shape&quot;:&quot;circle&quot;}\" data-widget_type=\"form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<form class=\"elementor-form\" method=\"post\" id=\"glp_aanmelding_onderaan\" name=\"GLP1 form\" aria-label=\"GLP1 form\">\n\t\t\t<input type=\"hidden\" name=\"post_id\" value=\"69922\"\/>\n\t\t\t<input type=\"hidden\" name=\"form_id\" value=\"2ac24f9\"\/>\n\t\t\t<input type=\"hidden\" name=\"referer_title\" value=\"Easly Shop\" \/>\n\n\t\t\t\n\t\t\t<div class=\"elementor-form-fields-wrapper elementor-labels-above\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-email elementor-field-group elementor-column elementor-field-group-email elementor-col-100 elementor-md-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-email\" class=\"elementor-field-label\">\n\t\t\t\t\t\t\t\tEmail\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"email\" name=\"form_fields[email]\" id=\"form-field-email\" class=\"elementor-field elementor-size-sm  elementor-field-textual\" required=\"required\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-group elementor-column elementor-field-type-submit elementor-col-33 e-form__buttons\">\n\t\t\t\t\t<button class=\"elementor-button elementor-size-sm\" type=\"submit\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Send<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/form>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8b481f2 e-flex e-con-boxed e-con e-parent\" data-id=\"8b481f2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f4d9cb elementor-widget elementor-widget-heading\" data-id=\"1f4d9cb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Sources:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0f84d6 elementor-widget elementor-widget-text-editor\" data-id=\"e0f84d6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Wetenschappelijke artikelen<\/b><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Drucker DJ. Mechanisms of Action and Therapeutic Application of Glucagon-Like Peptide-1. Cell Metabolism. 2018;27(4):740-756. DOI: 10.1016\/j.cmet.2018.03.001<\/span><\/li>\n<li>M\u00fcller TD, Finan B, Bloom SR, et al. Glucagon-like peptide 1 (GLP-1). Molecular Metabolism. 2019;30:72-130. DOI: 10.1016\/j.molmet.2019.09.010<\/li>\n<li>Wilding JPH, Batterham RL, Calanna S, et al.; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine. 2021;384(11):989-1002. DOI: 10.1056\/NEJMoa2032183<\/li>\n<li>Jastreboff AM, Aronne LJ, Ahmad NN, et al.; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine. 2022;387(3):205-216. DOI: 10.1056\/NEJMoa2206038<\/li>\n<li>Aronne LJ, Horn DB, le Roux CW, et al. Tirzepatide as compared with semaglutide for the treatment of obesity. SURMOUNT-5. New England Journal of Medicine. 2025. DOI: 10.1056\/NEJMoa2416394<\/li>\n<\/ul>\n<p><b>Nederlandse richtlijnen en kaders<\/b><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Farmacotherapeutisch Kompas. Preparaatteksten semaglutide, tirzepatide, liraglutide. Zorginstituut Nederland. Beschikbaar via: farmacotherapeutischkompas.nl<\/span><\/li>\n<li>Zorginstituut Nederland. GVS-advies semaglutide (Wegovy\u00ae) bij behandeling van obesitas. 2024. Beschikbaar via: zorginstituutnederland.nl<\/li>\n<li>NHG-Standaard Obesitas (versie 2.0, herzien). Nederlands Huisartsen Genootschap. Oktober 2025. Beschikbaar via: richtlijnen.nhg.org\/standaarden\/obesitas<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In this article, a pharmacist compares the efficacy, results, and legal frameworks of popular medications such as Ozempic, Wegovy, Mounjaro, and Saxenda. You will discover the crucial differences between these medicines, enabling you to have an informed and scientifically sound conversation with your doctor.<\/p>\n","protected":false},"author":6,"featured_media":69908,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2258],"tags":[],"class_list":["post-69922","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glp-1-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ozempic, Wegovy, Mounjaro or Saxenda: what is actually the difference? - Easly<\/title>\n<meta name=\"description\" content=\"Pharmacist compares Ozempic, Wegovy, Mounjaro, and Saxenda: active ingredient, indication, frequency, and research results scientifically substantiated.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.easly.nl\/en\/difference-ozempic-wegovy-mounjaro-saxenda\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ozempic, Wegovy, Mounjaro or Saxenda: what is actually the difference? 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