{"id":69199,"date":"2026-02-25T14:47:26","date_gmt":"2026-02-25T13:47:26","guid":{"rendered":"https:\/\/www.easly.nl\/biomarkers\/cyp2b6\/"},"modified":"2026-02-26T12:51:55","modified_gmt":"2026-02-26T11:51:55","slug":"cyp2b6","status":"publish","type":"biomarkers","link":"https:\/\/www.easly.nl\/en\/biomarkers\/cyp2b6\/","title":{"rendered":"CYP2B6"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"69199\" class=\"elementor elementor-69199 elementor-69171\" data-elementor-post-type=\"biomarkers\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6497400 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6497400\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-119b479\" data-id=\"119b479\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6566fc8 elementor-widget elementor-widget-heading\" data-id=\"6566fc8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What is CYP2B6?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76aaca3 elementor-widget elementor-widget-text-editor\" data-id=\"76aaca3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div id=\"model-response-message-contentr_e9f46e8acaf8e37a\" class=\"markdown markdown-main-panel stronger enable-updated-hr-color preserve-whitespaces-in-response\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<p data-path-to-node=\"0\">The CYP2B6 gene encodes an enzyme in the liver that plays a specialized role in processing a select but very important group of medications. This enzyme is unique because it is involved in both the breakdown of active substances and the activation of specific medications (such as certain forms of chemotherapy). Your CYP2B6 status is genetically determined; this means your personal profile remains the same throughout your life and is not influenced by factors that cause temporary changes in blood levels.<\/p>\n<p data-path-to-node=\"1\">The gene determines whether your body processes medication at the intended speed. If this pace deviates, it has direct consequences for the effectiveness of your treatment and the risk of unwanted side effects.<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fe4c473 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fe4c473\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4a209b8\" data-id=\"4a209b8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3fb196d elementor-widget elementor-widget-heading\" data-id=\"3fb196d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Why test your CYP2B6 status?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8a4275d elementor-widget elementor-widget-text-editor\" data-id=\"8a4275d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-path-to-node=\"0\">Because the activity of the CYP2B6 enzyme varies significantly per person, a standard dose may be unsafe or insufficiently effective for you. Insight into your profile helps in making the right treatment choices:<\/p>\n<ul>\n<li data-path-to-node=\"1,0,0\"><b data-path-to-node=\"1,0,0\" data-index-in-node=\"0\">Risk of treatment failure (Prodrugs):<\/b> Some medications, including certain chemotherapies, must be &#8216;converted&#8217; by CYP2B6 to work. With slow enzyme activity, the medication does not become active enough, causing the treatment to lose its potency.<\/li>\n<li data-path-to-node=\"1,1,0\"><b data-path-to-node=\"1,1,0\" data-index-in-node=\"0\">Accumulation of side effects:<\/b> For active medications broken down by this enzyme, delayed action can lead to excessively high concentrations in the blood, significantly increasing the risk of serious side effects.<\/li>\n<li data-path-to-node=\"1,2,0\"><b data-path-to-node=\"1,2,0\" data-index-in-node=\"0\">Rapid clearance:<\/b> With an overactive enzyme, medication is removed from your system so quickly that a sufficiently high level is never reached to be effective.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1a1ced2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1a1ced2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-981a0f1\" data-id=\"981a0f1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef9e6ed elementor-widget elementor-widget-heading\" data-id=\"ef9e6ed\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Medications where CYP2B6 plays a role<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ecb1549 elementor-widget elementor-widget-text-editor\" data-id=\"ecb1549\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-path-to-node=\"0\">This enzyme is of great importance in the metabolism of, among others, the following agents:<\/p>\n<ul>\n<li data-path-to-node=\"1,0,0\"><b data-path-to-node=\"1,0,0\" data-index-in-node=\"0\">Antidepressants &amp; Smoking Cessation:<\/b> e.g., Bupropion (Wellbutrin\/Zyban).<\/li>\n<li data-path-to-node=\"1,1,0\"><b data-path-to-node=\"1,1,0\" data-index-in-node=\"0\">HIV medication:<\/b> e.g., Efavirenz and Nevirapine.<\/li>\n<li data-path-to-node=\"1,2,0\"><b data-path-to-node=\"1,2,0\" data-index-in-node=\"0\">Chemotherapy:<\/b> e.g., Cyclophosphamide and Ifosfamide.<\/li>\n<li data-path-to-node=\"1,3,0\"><b data-path-to-node=\"1,3,0\" data-index-in-node=\"0\">Pain management &amp; Addiction care:<\/b> e.g., Methadone and Ketamine.<\/li>\n<li data-path-to-node=\"1,4,0\"><b data-path-to-node=\"1,4,0\" data-index-in-node=\"0\">Anesthetics:<\/b> e.g., Propofol.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-982da15 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"982da15\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-be1a250\" data-id=\"be1a250\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53fa0aa elementor-widget elementor-widget-heading\" data-id=\"53fa0aa\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Interpretation of your CYP2B6 status<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89e8d42 elementor-widget elementor-widget-text-editor\" data-id=\"89e8d42\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Based on your DNA analysis, you are classified into one of four metabolism types. This provides immediate insight into how your body responds to the mentioned medications:<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a79752f elementor-widget elementor-widget-shortcode\" data-id=\"a79752f\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-211\" class=\"tablepress tablepress-id-211 biomarker-table\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Result<\/th><th class=\"column-2\">Interpretatie<\/th><th class=\"column-3\">Interpretation<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"row-2\">\n\t<td class=\"column-1\">PM<\/td><td class=\"column-2\">Poor Metabolizer <br \/>\n(Non-expressor)<\/td><td class=\"column-3\">The enzyme is inactive. This is the case for most Europeans. You have an increased risk of side effects with standard doses of specific medications.<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">IM<\/td><td class=\"column-2\">Intermediate Metabolizer<\/td><td class=\"column-3\">The enzyme exhibits limited activity. Medication processing is slower than average, often requiring careful dosing.<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">NM<\/td><td class=\"column-2\">Normal Metabolizer<br \/>\n(Expressor)<\/td><td class=\"column-3\">The enzyme is active and functioning normally. Certain medications (such as tacrolimus) are broken down more quickly, so a higher dose is often required for effectiveness.<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">UM<\/td><td class=\"column-2\">Ultrarapid Metabolizer<\/td><td class=\"column-3\">The enzyme works extremely quickly. Medication is removed from the body very quickly, which increases the risk of insufficient effectiveness of the therapy.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-41efbb8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"41efbb8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44e0e68\" data-id=\"44e0e68\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e5c1f13 elementor-widget elementor-widget-heading\" data-id=\"e5c1f13\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Medical interpretation &amp; advice<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c775d44 elementor-widget elementor-widget-text-editor\" data-id=\"c775d44\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Your test results from Easly are cross-referenced with the official medication guidelines of the <b data-path-to-node=\"0\" data-index-in-node=\"97\">KNMP (G-Standard)<\/b>. This provides you, your pharmacist, and your doctor with a scientific foundation for a personalized treatment plan.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88ff70c elementor-widget elementor-widget-text-editor\" data-id=\"88ff70c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Important: Always use this result in consultation with your treating physician or pharmacist. Never adjust your dosage independently.<\/strong> Based on your profile, a doctor or pharmacist may decide to optimize the dose or switch to a medication that does not depend on this specific enzyme.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-c87ea87 e-flex e-con-boxed e-con e-parent\" data-id=\"c87ea87\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7f1420 elementor-widget elementor-widget-image\" data-id=\"c7f1420\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.easly.nl\/en\/dna-passport-for-medication\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1260\" height=\"460\" src=\"https:\/\/www.easly.nl\/wp-content\/uploads\/sites\/13\/2026\/02\/Farmaco-biomarker-banner-1.png\" class=\"attachment-full size-full wp-image-69003\" alt=\"Farmaco biomarker banner\" srcset=\"https:\/\/www.easly.nl\/wp-content\/uploads\/sites\/13\/2026\/02\/Farmaco-biomarker-banner-1.png 1260w, https:\/\/www.easly.nl\/wp-content\/uploads\/sites\/13\/2026\/02\/Farmaco-biomarker-banner-1-300x110.png 300w, https:\/\/www.easly.nl\/wp-content\/uploads\/sites\/13\/2026\/02\/Farmaco-biomarker-banner-1-1024x374.png 1024w, https:\/\/www.easly.nl\/wp-content\/uploads\/sites\/13\/2026\/02\/Farmaco-biomarker-banner-1-768x280.png 768w, https:\/\/www.easly.nl\/wp-content\/uploads\/sites\/13\/2026\/02\/Farmaco-biomarker-banner-1-804x294.png 804w, https:\/\/www.easly.nl\/wp-content\/uploads\/sites\/13\/2026\/02\/Farmaco-biomarker-banner-1-1044x381.png 1044w\" sizes=\"(max-width: 1260px) 100vw, 1260px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ac8bce9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ac8bce9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c770759\" data-id=\"c770759\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fef789e elementor-widget elementor-widget-text-editor\" data-id=\"fef789e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div id=\"model-response-message-contentr_bb829c98fccf1116\" class=\"markdown markdown-main-panel stronger enable-updated-hr-color preserve-whitespaces-in-response\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<div id=\"model-response-message-contentr_337f0d8bc8e76c2d\" class=\"markdown markdown-main-panel stronger enable-updated-hr-color preserve-whitespaces-in-response\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<p data-path-to-node=\"0\"><strong>Don&#8217;t keep struggling with unexplained side effects.<\/strong><\/p>\n<p data-path-to-node=\"0\">Do you want to know if your symptoms can be explained by your DNA profile? Take the free <a href=\"https:\/\/www.easly.nl\/en\/dna-paspoort-test-online\/\"><b data-path-to-node=\"0\" data-index-in-node=\"142\">Pharmacogenetic Quickscan<\/b><\/a> (Only available in Dutch) and get immediate clarity on whether a test is right for you.<\/p>\n<\/div>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe9acf7 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"fe9acf7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.easly.nl\/en\/dna-paspoort-test-online\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Start the Quick Scan<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Discover how your CYP2B6 gene affects the breakdown of medications such as antidepressants and chemotherapy, so you can determine the safest dosage together with your doctor.<\/p>\n","protected":false},"template":"","biomarkers_category":[2233],"class_list":["post-69199","biomarkers","type-biomarkers","status-publish","hentry","biomarkers_category-pharmacogenetics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CYP2B6 DNA Test: Prevent Side Effects &amp; Optimize Medication<\/title>\n<meta name=\"description\" content=\"Does your CYP2B6 status influence the effectiveness of antidepressants or chemotherapy? 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